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The plot of Love and Other Drugs revolves around the character of Maggie (portrayed by Hathaway). She is a free spirited girl who loves to live a life of always single and ever ready to mingle without any hassles of tied relationship. In parallel to her stands the character of Jamie, played by Jake Gyllenhaal who is a successful pharmaceutical salesman. His flamboyant nature and infallible charms makes him popular and wanted among the ladies. The two characters Maggie living in her free spirited world and Jamie living in his cutthroat pharmaceutical world meets each other to discover another world in them, it is the world that is drugged by love.