The majority of couples who undergo screening do so due to their advanced ages or due to various pre-existing issues surrounding conditions like past miscarriages and chromosomal abnormalities. The success rates of patients who undergo screening can vary widely since many tested embryos are not suitable for transfer and depend on an individual’s circumstance. Some success rates for couples who have submitted to screening before transfer in the past few years are:
– 0 success of live birth out of 12 attempts of women over the ages of 44
– 1 success of live birth out of 29 attempts of women over the ages of 42-44
– 12 success of live birth out of 42 attempts of women over the ages of 39-42
– 7 success of live birth out of 25 attempts of women over the ages of 37-39
– 2 success of live birth out of 15 attempts of women over the ages of 34-37
– 2 success of live birth out of 7 attempts of women under the age of 35
These rates or for a small selection of women with a range of demographics and issues. Each of those in the study participated in at least 50 cycles of infertility treatment and those that were started or resulted in a live birth are calculated in these figures.
In recent studies, researchers have questioned if couples seeking screening actually increase their chances of a live birth. According to those studies, there is little evidence that the screening increases the success rate, but there is a lower number of live births that are afflicted with chromosomal defects thanks to the screening. Additional random and control trials are needed to ascertain a more accurate count of the success rates due to screenings.
Infertility centers are required by law to validate their use of the screening for each section patients its offered to. They are also required to record the particulars of the patient’s issues such as age, implantation failure, male infertility and so on.
Like IVF itself, there are similar risk to the patient and embryo during the screening process. Some dangers that are unique to PGS screening are embryo damage during cell removal which can result in the destruction of a viable egg. Also, it can result in the loss of all viable, transferable embryos after testing. Just as there are no guarantees that an IVF procedure will work, there are also no assurances that testing will result in successful implantation.
Preimplantation genetic screening is based on a theory that all human embryo cells are the same chromosomally. By removing and testing one cell, it should accurately chart the health of the remaining cells in the embryo. Research however has proved that there are mosaic embryos, or those that are not chromosomally identical that are often discarded during testing when they were perfectly viable for transfer.
To find out more about preimplantation genetic screening, you can search the clinic database on the CDC website to find infertility clinics that offer the screening. Before moving ahead with preimplantation genetic screening, it is advisable to speak with your infertility care specialist to understand the risk and options available to you.